Laboratoire Charles Coulomb UMR 5221 CNRS/UM2 (L2C)

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Photo de WALTER Jean-charles
WALTER Jean-Charles      
Fonction : Chercheur
Organisme : CNRS
Chargé de Recherche
(HDR)
Encadre la thèse de : CHEVALIER C.,
Autre(s) thème(s) de recherche ou rattachement(s) :
 - Physique théorique des systèmes biologiques
 - Physique Non-linéaire
jean-charles.walter_AT_umontpellier.fr
Bureau: 51, Etg: 1, Bât: 13 - Site : Campus Triolet

Curriculum Vitae:     
2017-present: Researcher at L2C, CNRS, Montpellier
2013-2017: Postdoc, L2C, Université de Montpellier
2012: Postdoc, Lorentz Institute, University of Leiden, The Netherlands
2009-2011: Postdoc, Institute for Theoretical Physics, KULeuven
2009: PhD, Université Henri Poincaré, Nancy, France
Activités de Recherche:     
I am a theoretical physicist interested in the description of biological processes. The functioning of a cell requires the coordinated motion and positioning of various actors among which biopolymers - RNA and DNA - and proteins. Their interactions - and subsequent reaction and motion - can be described with a physical approach. My current projects include: (i) the description of DNA organization and segregation in bacteria (ii) the translation process in human cells through the recruitment and motion of ribosomes on messenger RNA (iii) the epigenetic regulation of gene expression in eukaryotes via polycomb domains.

Co-organizer (with I. Junier and J-Y. Bouet) of "Bacterial DNA supercoiling @ Sète" Nov. 2019 & Oct. 2020, Sète, France.

Current fundings: ANR (CBS, L2C) "Flagellar Motor" (2018-2021); flagship project LabEx NUMEV (IGF, LIRMM, L2C) ''Gene Expression Modeling" (2017-2020); LabMuse PhD training network (CBS, IGH, L2C) on the epigenetic regulation of gene expression via polycomb domains (2020-2023).
Projets de Recherche:
Funding MITI-CNRS: Sensing DNA supercoiling in vivo by combining polymer physics and molecular biology (2019-2020)
Domaines de Recherche:
  • Physique/Physique/Biophysique
HDR
+ Modeling the formation and positioning of intracellular macromolecular assemblies: Application to bacterial DNA segregation hal link

Auteur(s): Walter J.-C.

(H.D.R.) , 2020
Texte intégral en Openaccess : fichier pdf

Dernieres productions scientifiques :
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+ Modelling the effect of ribosome mobility on the rate of protein synthesis (vol 44, 19, 2021) doi link

Auteur(s): Dauloudet O., Neri I., Walter J.-C., Dorignac J., Geniet F., Parmeggiani A.

(Article) Publié: European Physical Journal E, vol. 44 p.60 (2021)
Texte intégral en Openaccess : openaccess

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+ Physical modeling of the ParBS complex: insight into Liquid-Liquid Phase Separation hal link

Auteur(s): Walter J.-C.(Corresp.)

Conférence invité: BioPhyChrom 2021 (The biology and physics of bacterial chromosome organization) (Leiden, NL, 2021-04-29)

Texte intégral en Openaccess : fichier pdf

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+ Supercoiled DNA and non-equilibrium formation of protein complexes: A quantitative model of the nucleoprotein ParBS partition complex doi link

Auteur(s): Walter J.-C.(Corresp.), Lepage Thibaut, Dorignac J., Geniet F., Parmeggiani A., Palmeri J., Bouet Jean-Yves, Junier Ivan

(Article) Publié: Plos Computational Biology, vol. 14 p.e1008869 (2021)
Texte intégral en Openaccess : openaccess

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+ Physical modeling of a sliding clamp mechanism for the spreading of ParB at short genomic distance from bacterial centromere sites doi link

Auteur(s): Walter J.-C.(Corresp.), rech jerome, Walliser N.-O., Dorignac J., Geniet F., Palmeri J., Parmeggiani A., Bouet Jean-yves

(Article) Publié: Iscience, vol. 23 p.101861 (2020)
Texte intégral en Openaccess : openaccess

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+ Modeling supercoiled DNA interacting with an anchored cluster of proteins: towards a quantitative estimation of chromosomal DNA supercoiling arxiv link

Auteur(s): Walter J.-C.(Corresp.), Lepage Thibaut, Dorignac J., Geniet F., Parmeggiani A., Palmeri J., Bouet Jean-Yves, Junier Ivan

(Document sans référence bibliographique) 2020-04-07
Texte intégral en Openaccess : arxiv

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