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Stepping and Crowding of Molecular Motors: Statistical Kinetics from an Exclusion Process Perspective
Auteur(s): Parmeggiani A.
Conférence invité: TASEP Conference at the Vrjie Universität (Amsterdam, NL, 2015-06-11)
Résumé: Collective stochastic of motor proteins transport
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Physics of Traffic in the Self-Organized Cytoplasm
Auteur(s): Parmeggiani A.
Conférence invité: Rencontres Scientifiques des Grands Causses (Millau, FR, 2015-09-28)
Résumé: Theoretical physics of motor protein collective transport in the cytoplasm
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Collective phenomena in intracellular transport and logistics
Auteur(s): Parmeggiani A.
Conférence invité: Molecule Trajectories in Cellular Spaces (Lyon, FR, 2015-11-16)
Résumé: Theoretical physics of collective phenomena in intracellular transport and logistics
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Instabilities and shape variation phase transitions in tubular lipid membranes 
Auteur(s): Golushko I., Rochal S. B., Parmeggiani A., Lorman V.
(Document sans référence bibliographique) 2015-01-01Texte intégral en Openaccess : 
Ref HAL: hal-01935603_v1
Ref Arxiv: 1501.00258
Ref. & Cit.: NASA ADS
Exporter : BibTex | endNote
Résumé: Changes of external parameters in proximity of critical point can increase thermal fluctuations of tubular lipid membrane (TLM) and result in variation of the membrane shape. The phase transitions in the system are shown to be controlled by a single effective parameter, which depends on the pressure difference between inner and outer regions of membrane and the applied stretching force. We determine an interval of the parameter values corresponding to the stability region of the cylindrical shape of TLM and investigate the behavior of the system in the vicinity of critical instabilities, where the cylindrical shape of membrane becomes unstable with respect to thermal fluctuations. The applied boundary conditions strongly influence the behavior of TLM. For example, small negative effective parameter corresponds to chiral shape of TLM only in the case of periodic boundary conditions. We also discuss other three types of phase transitions emerging in the system.
Commentaires: 15 pages, 6 figures, in Russian
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Fundamental Problems in Statistical Physics XIII Special Issue Preface
Auteur(s): Baiesi M., Carlon E., Parmeggiani A.
(Article) Publié:
Physica A: Statistical Mechanics And Its Applications, vol. 418 p.1-5 (2015)
Ref HAL: hal-01200630_v1
DOI: 10.1016/j.physa.2014.08.010
WoS: WOS:000346213300001
Exporter : BibTex | endNote
Résumé: The 13th edition of the International Summer School on Fundamental Problems in Statistical Physics took place from June 16 to 29, 2013 for the third consecutive time in “European Center La Foresta” in Leuven, Belgium. This special issue of Physica A publishes the proceedings of the school.
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Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus
Auteur(s): Sanchez Aurore, Cattoni Diego, Walter J.-C., Rech Jérôme, Parmeggiani A., Nollmann Marcelo, Bouet Jean-Yves
(Article) Publié:
Cell Systems, vol. 1 p.163-173 (2015)
Texte intégral en Openaccess : 
Ref HAL: hal-01191677_v1
DOI: 10.1016/j.cels.2015.07.013
WoS: 000209925700010
Exporter : BibTex | endNote
60 Citations
Résumé: Many canonical processes in molecular biology rely on the dynamic assembly of higher-order nucleoprotein complexes. In bacteria, the assembly mechanism of ParABS, the nucleoprotein super-complex that actively segregates the bacterial chromosome and many plasmids, remains elusive. We combined super-resolution microscopy, quantitative genome-wide surveys, biochemistry, and mathematical modeling to investigate the assembly of ParB at the centromere-like sequences parS. We found that nearly all ParB molecules are actively confined around parS by a network of synergistic protein-protein and protein-DNA interactions. Interrogation of the empirically determined, high-resolution ParB genomic distribution with modeling suggests that instead of binding only to specific sequences and subsequently spreading, ParB binds stochastically around parS over long distances. We propose a new model for the formation of the ParABS partition complex based on nucleation and caging: ParB forms a dynamic lattice with the DNA around parS.This assembly model and approach to characterizing large-scale, dynamic interactions between macro-molecules may be generalizable to many unrelated machineries that self-assemble in superstructures.
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Influence of boundary conditions on instabilities and shape phase transitions in tubular lipid membranes
Auteur(s): Ivan Golushko, Rochal S.B., Parmeggiani A., Lorman V.
Conference: 49th Winter School on Condensed Matter Physics (St. Petersbourg, RU, 2015-03-16)
Ref HAL: hal-01163679_v1
Exporter : BibTex | endNote
Résumé: Influence of boundary conditions on instabilities and shape phase transitions in tubular lipid membranes
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