|Nanostructuring of hybrid silicas: New approach to bridged silsesquioxanes with purine-pyrimidine base pairs as bridging units |
Conference: Symposium on Organic-Inorganic Hybrid Materials (San Francisco (CA), FR, 2007-04-09)
A new route to synthesize hybrid silica-based network with. bridging, organic units via molecular recognition is described. The hydrolysis of two monosilylated complementary base pairs, one bearing an adenine fragment and the other a thymine fragment leads to the formation of a powdered sample that has been characterized by Scanning Electron Microscopy (SEM), Powder X-ray Diffraction (PXRD) FTIR and solid state NMR (H-1, C-13 and Si-29). This last technique proved to be extremely powerful to directly demonstrate the occurrence of heteroassembly of the nucleobase-based silylated fragments, through the use of two-dimensional H-1 double-quanta MAS-NMR that could probe spatial proximities between the thymine NH groups and the adenine NH2 groups.