Ref HAL: hal-00004353_v1
PMID 16032840
Ref Arxiv: cond-mat/0503084
DOI: 10.1021/la0468500
WoS: 000228983700013
Ref. & Cit.: NASA ADS
Exporter : BibTex | endNote
159 Citations
Résumé:

Polypeptide-based diblock copolymers forming either well-defined self-assembled micelles or vesicles after direct dissolution in water or in dichloromethane, have been studied combining light and neutron scattering with electron microscopy experiments. The size of these structures could be reversibly manipulated as a function of environmental changes such as pH and ionic strength in water. Compared to other pH-responsive seld-assembled systems based on "classical" polyelectrolytes, these polypeptide-based nanostructures present the ability to give a response in highly salted media as the chain conformational ordering can be controlled. This makes these micelles and vesicles suitable for biological applications: they provide significant advantages in the control of the structure and function of supramolecular self-assemblies.