Sommaire:

The characterization of the genomic structural and functional state has been boosted by the concomitant development of different genomic techniques. Each of these experiments gives an extra layer of information from the localization on the genome sequence of histone modifications and transcription factor binding sites (Chip-seq) to the frequency of interactions of genomic loci (Hi-C). The interpretation of these data has been facilitated by complementary computational techniques. I contributed to these computational efforts by developing molecular dynamics approaches for modeling genome architecture and dynamics. After reviewing my doctoral and postdoctoral activities, I will discuss my research's latest developments concerning the generation of 3D models of the A. thaliana genome. Finally, I will briefly discuss how I plan to extend the genome-wide modeling approach in the next years.

References
Di Stefano M, Nützmann H-W, Marti-Renom MA, Jost D. Polymer modelling unveils the roles of heterochromatin and nucleolar organizing regions in shaping 3D genome organization in Arabidopsis thaliana. bioRxiv. 2020. p. 2020.05.15.098392. doi:10.1101/2020.05.15.098392

Andrea Parmeggiani's Zoom Meeting - Seminar Marco Di Stefano
Lunedì, 14 dicembre⋅14:55 – 16:55
Luogo:
https://umontpellier-fr.zoom.us/j/87126724144?pwd=cEp0UUFLN2hOMWJ0WlA0YUpoNE4yUT09
Descrizione:Andrea Parmeggiani vous invite à une réunion Zoom planifiée.

Participer à la réunion Zoom
https://umontpellier-fr.zoom.us/j/87126724144?pwd=cEp0UUFLN2hOMWJ0WlA0YUpoNE4yUT09

ID de réunion : 871 2672 4144
Code secret : 749330

Pour plus d'informations, merci de contacter Parmeggiani A.