Jeu. 04/03/2021 15:00 Webinar
WINGREEN Ned (Lewis-Sigler Institute of Integrative Genomics, Princeton University)
Phase separation inside cells
Biologists have recently come to appreciate that eukaryotic cells are home to a multiplicity of non-membrane bound compartments, many of which form and dissolve as needed for the cell to function. These dynamical “condensates” enable many central cellular functions – from ribosome assembly, to RNA regulation and storage, to signaling and metabolism. While it is clear that these compartments represent a type of separated phase, what controls their formation, how specific biological components are included or excluded, and how these structures influence physiological and biochemical processes present many open questions. I will discuss recent experiments on phase separated condensates both engineered and natural, and will discuss a novel “magic number” effect relevant to the formation and control of two-component phase separated condensates.
Pour plus d'informations, merci de contacter Palmeri J.