Sommaire:

Nanophotonics refers to the unique interactions of light (photonics) and materials at the nanometer scale. Nanometer sized metals (e.g. gold, silver, copper) exhibit extremely high electric field enhancements when excited by laser light, leading to unique opportunities in sensing and therapy in cancer applications. Therapeutically, this interaction can be used to generate heat and mechanical shock waves (nanobubbles) that serve to release drugs, denature proteins, or disrupt cell membranes. We’ve demonstrated these effects can illicit a specific type of cell death that stimulates the body’s immune system to fight cancer in models of breast cancer and melanoma. Diagnostically, these nanomaterials enable a sensing platform using surface enhanced Raman scattering (SERS) that greatly enhances the detection ability of molecules near the particle surface. We are developing implantable devices with SERS sensors to monitor patients at risk for cancer recurrence after treatments.

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