Sommaire:

Living organisms use dynbamic, isothermal processes like self-organization to function and evolve. Imitating these processes with synthetic soft matter can lead to innovative and bio-inspired materials. DNA nanotechnology offers programmability and versatility for creating desired 2D and 3D nanostructures. Although reconfigurability of DNA nanostructures is possible, building growing and evolving structures is still challenging. Our recent work in Damien Baigl’s team demonstrated that using an adjusted salted buffer allows DNA strands to self-assemble into programmed and reconfigurable morphologies at room temperature [1]. In this seminar, I will discuss how we can go further self-assemble DNA nanostructures at 37°C in bio-relevant buffers, and notably in the presence of cells. I will also show that the method enabled us to induce the living growth of DNA nanotubes, either in bulk solution or inside biomimetic micro-compartments. Finally, I will present the self-organization of nanotubes with electrostatic interactions, resulting into large DNA superstructures that exhibit reversible dynamics triggered by external stimuli. All these results open up perspectives for the development of dynamic and evolving architectures inside living and/or temperature-sensitive environments. 1. Rossi-Gendron, C.; El Fakih, F.; Bourdon, L.; Nakazawa, K.; Finkel, J.; Triomphe, N.; Chocron, L.; Endo, M.; Sugiyama, H.; Bellot, G.; et al. Isothermal Self-Assembly of Multicomponent and Evolutive DNA Nanostructures. Nat. Nanotechnol. 2023, doi:LF.LF38/s41565-023-01468-2.

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