Sommaire:

Our work is characterised by its interdisciplinarity, at the interface of Physics with Biology and Computer Sciences. It aims at highlighting how in silico experiments based on statistical Physics principles and intensive simulations allow answering targeted applied questions of high impact in domains ranging from plant biotechnology to human metabolism. We focus on complex coarse-grained macromolecular systems and non-equilibrium and non-linear phenomena. With our approach based on kinetic Monte Carlo simulations, we mainly investigate two types of systems: i) one-dimensional and unidirectional transport processes (e.g. the cytoskeletal transport, and the translation of mRNAs by ribosomes), and ii) the emergence of complex three-dimensional polysaccharidic structures (e.g. starch, glycogen, and lignocellulose) resulting from either synthesising or degrading enzymatic activities.

Pour plus d'informations, merci de contacter Parmeggiani A.