Sommaire:

The importance of using micro- and nano-vectors in drug delivery is a well established issue. Design and preparation of the appropriate vectors for each application requires extensive preliminary studies. These include the search among similar systems, the synthesis of new molecules and the structural characterization of loaded vectors. In fact, trial and error procedures for in vitro and in vivo experiments are costly, time consuming and can imply ethical concerns. Therefore, these procedures should be limited as strictly as possible. In this seminar examples of physico-chemical characterization will be discussed for self assembling structures loaded with anticancer agents, antibacterial drugs or small interfering RNA (siRNA). In particular, liposomes containing boronated componds for Boron Neutron Capture Therapy and Resveratrol against Helicobacter Pylori will be described, along with cationic micelles as possible carriers for siRNA. The information obtained by different methods, such as small angle scattering and magnetic resonance, will be correlated to the association mechanism, the insertion modality and the efficacy of drug delivery.

Pour plus d'informations, merci de contacter Stocco A.