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Spectroscopies vibrationnelles Infrarouge et Raman
(2) Production(s) de l'année 2022
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Therapeutic targeting of CDK4 kinase in pancreatic cancerusing functionalized single-walled carbon nanotubes 
Auteur(s): Chavignon L. , Blanc C., Morris May, Anglaret E.
(Affiches/Poster)
Chemontubes 2022 (San Sebastian, ES), 2022-04-24
Ref HAL: hal-03859686_v1
Exporter : BibTex | endNote
Résumé: Pancreatic cancer is one of the deadliest cancers with an increasing incidence due to a lack ofearly-stage diagnostics and effective treatment [1]. The RAS/RAF/ MAPK/CDK4 pathway is frequentlydysregulated in pancreatic cancer and CDK4 constitutes an attractive target since several drugs havebeen approved by the FDA to inhibit its activity: Abemaciclib, Ribociclib and Palbociclib [2,3] (Figure1) However these inhibitors are not efficient in monotherapy and have only been approved for breastcancer. In order to propose an efficient therapeutic strategy to target CDK4 in pancreatic cancer, wepropose to deliver Abemaciclib using carbon nanotubes.
Carbon nanotubes are promising materials for nanomedicine applications and especially fordrug delivery. [4] In this project, we adsorb Abemaciclib onto single-walled carbon nanotubes (SWNT)for delivery of the drug into pancreatic cancer cells. In order to study adsorption, we investigate thechanges in the optical signatures of SWNTs in the near-infrared (NIR) by coupling NIR absorption,photoluminescence and Raman spectroscopies. [5] Typical kinetic spectroscopic results, assigned tothe adsorption of Abemaciclib on SWNT, dispersed in water using carbomethylcellulose (CMC), arepresented in Figure 2. We discuss the results in terms of changes of the dielectric environment of thenanotubes, leading to modulation of their excitonic and optical properties. We have furtherinvestigated the inhibitory potential of SWNT-Abemaciclib on proliferation of PANC1 cells comparedto Abemaciclib alone and have determined the toxicthreshold of SWNT dispersed in CMC.
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Piezoelectricity and Related Properties in Orthorhombic Cadmium Diiodate
Auteur(s): Azeroual H., Bantignies J.-L., Alvarez L., Maurin D., Granier D., Haines J., Cambon O., Hermet P.
(Article) Publié:
Journal Of Materials Chemistry C, vol. 10 p.9499-9511 (2022)
Texte intégral en Openaccess : 
Ref HAL: hal-03759175_v1
DOI: 10.1039/D2TC00769J
Exporter : BibTex | endNote
Résumé: We report a complete investigation of the structural, electronic, vibrational, elastic and piezoelectric properties of the P2 1 2 1 2 1 orthorhombic phase in cadmium diiodate (δ-Cd(IO 3) 2) by combining experiments and first-principles based calculations. We revisited the nature of the electronic band gap and suggest an indirect band gap with a value of 4.6 eV. The infrared and Raman responses were measured and the different phonon modes assigned. To date, the δ-Cd(IO 3) 2 piezoelectric response remains unknown. We reported the different mechanisms involved in its piezoelectric response from the density functional perturbation theory. The highest value of the piezoelectric-stress and piezoelectric-strain constants in the zero Kelvin limit is predicted for e 41 =-0.27 C/m 2 and d 41 =-10.32 pC/N. These sizable values associated with the thermal stability (no phase transition up to the thermal decomposition at 550°C) and a relative large electronic band gap make δ-Cd(IO 3) 2 a potential candidate for piezoelectric applications.
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