Nos tutelles

À noter

Nos partenaires

Rechercher

Facebook |

Twitter

Accueil > Production scientifique

Recherche approfondie

par Année

par Auteur

par Thème

par Type

Dynamique et rhéologie des fluides complexes (gels, polymères, mousses, colloïdes)
(23) Production(s) de l'année 2021

1 2 3 4

Enhanced microscopic dynamics in mucus gels under a mechanical load in the linear viscoelastic regime

Auteur(s): Larobina Domenico, Pommella A., Philippe A. M., Nagazi M. Y., Cipelletti L. (Corresp.)

(Article) Publié: Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 118 p.e2103995118 (2021)
Texte intégral en Openaccess :

Ref HAL: hal-03648934_v1
Ref Arxiv: 2110.01097
DOI: 10.1073/pnas.2103995118
WoS: WOS:000720926900021
Ref. & Cit.: NASA ADS
Exporter : BibTex | endNote
Résumé:

Mucus is a biological gel protecting several tissues. Its key properties result from a crucial balance between solid-like and fluid-like behavior, ensured by the nonpermanent nature of the bonds between its macromolecular constituents. Our understanding of the micrometer-scale response of mucus to an applied stress is still rudimentary, although in living organisms, stresses acting on mucus are ubiquitous, from bacterial penetration to coughing and peristalsis. We show that under a modest applied stress, in the mechanical linear regime, the microscopic dynamics of pig gastric mucus transiently accelerate by up to 2 orders of magnitude. A simple model rationalizes this previously unrecognized fluidization mechanism stemming from elastic recoil following bond breaking and generalizes our findings to networks with reversible bonds.Mucus is a biological gel covering the surface of several tissues and ensuring key biological functions, including as a protective barrier against dehydration, pathogen penetration, or gastric acids. Mucus biological functioning requires a finely tuned balance between solid-like and fluid-like mechanical response, ensured by reversible bonds between mucins, the glycoproteins that form the gel. In living organisms, mucus is subject to various kinds of mechanical stresses, e.g., due to osmosis, bacterial penetration, coughing, and gastric peristalsis. However, our knowledge of the effects of stress on mucus is still rudimentary and mostly limited to macroscopic rheological measurements, with no insight into the relevant microscopic mechanisms. Here, we run mechanical tests simultaneously to measurements of the microscopic dynamics of pig gastric mucus. Strikingly, we find that a modest shear stress, within the macroscopic rheological linear regime, dramatically enhances mucus reorganization at the microscopic level, as signaled by a transient acceleration of the microscopic dynamics, by up to 2 orders of magnitude. We rationalize these findings by proposing a simple, yet general, model for the dynamics of physical gels under strain and validate its assumptions through numerical simulations of spring networks. These results shed light on the rearrangement dynamics of mucus at the microscopic scale, with potential implications in phenomena ranging from mucus clearance to bacterial and drug penetration.ASCII and Excel files for all the datasets shown in the figures of the main text and SI Appendix have been deposited in Zenodo (DOI: 10.5281/zenodo.5533877) (74).

Glass: We love it but it breaks

Auteur(s): Kob W. (Corresp.)

Conférence invité: 14th Pacific rim conference on ceramic and glass technology (Vancouver, CA, 2021-12-13)

Hunting for order in disordered systems

Auteur(s): Kob W.

Conférence invité: Colloque de lancement MIPS (Montpellier, FR, 2021-11-08)

On the structure of amorphous systems: More order than expected

Auteur(s): Kob W.

Conférence invité: Journées de la Matière Condensée 17 (Rennes, FR, 2021-08-24)

On the structure of amorphous systems on intermediate and large length scales

Auteur(s): Kob W.

Conférence invité: Local structure meets machine learning in soft matter systems (Lausanne, CH, 2021-06-28)

Properties of oxide glass surfaces at the nanoscale

Auteur(s): Kob W. (Corresp.)

Conférence invité: Glass Summit 2021 (Corning, US, 2021-06-08)

Nanocomposites and Gels: Insight from atomistic Simulations

Auteur(s): Kob W. (Corresp.)

(Séminaires) Institute of Natural Sciences, Shanghai Jiao Tong University (Shanghai, CN), 2021-05-18

1 2 3 4

Menu

Nos tutelles

À noter

Contacts

Localisation

Emplois, Thèses, Stages

Nos partenaires

Rechercher

Recherche approfondie

Dynamique et rhéologie des fluides complexes (gels, polymères, mousses, colloïdes)
(23) Production(s) de l'année 2021

Menu

Nos tutelles

À noter

Contacts

Localisation

Emplois, Thèses, Stages

Nos partenaires

Rechercher

Recherche approfondie

Dynamique et rhéologie des fluides complexes (gels, polymères, mousses, colloïdes)(23) Production(s) de l'année 2021

Dynamique et rhéologie des fluides complexes (gels, polymères, mousses, colloïdes)
(23) Production(s) de l'année 2021