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Production scientifique
Physique théorique des systèmes biologiques
(25) Production(s) de l'année 2018
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Influence of chemical and geometrical modifications on nanopore conductivity
Auteur(s): Manghi Manoel, Palmeri J., Loubet Bastien
Conférence invité: PHYSICS OF MEMBRANE PROCESSES (PMP2018) (Bologna, IT, 2018-09-02)
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Projet Étendard LabEx NUMEV GEM (Gene Expression Modeling)
Auteur(s): Palmeri J.
Conférence invité: LabEx NUMEV : Journée Bilan et Perspectives, (Montpellier, FR, 2018-05-18)
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Theoretical insights of electrolyte transport in nanopores
Auteur(s): Manghi Manoel, Palmeri J., Loubet Bastien
Conférence invité: JOURNÉES DE LA MATIÈRE CONDENSÉE 2018 (JMC2018) (Grenoble, FR, 2018-08-27)
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Physique théorique des systèmes biologiques
Auteur(s): Palmeri J.
Conférence invité: Etonnant Vivant (Montpellier, FR, 2018-04-03)
Ref HAL: hal-01947443_v1
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Résumé: Nous présentons plusieurs applications de la Physique Statistique aux systèmes biologiques.
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Laboratory of Excellence NUMEV: Digital and Hardware Solutions, Environmental and Organic Life Modeling
Auteur(s): Parmeggiani A.
Conférence invité: UC-Davis at MUSE-Unversity in Montpellier (Montpellier, FR, 2018-09-07)
Ref HAL: hal-02106125_v1
Exporter : BibTex | endNote
Résumé: NUMEV activities presentation during the visit of UC-Davis University in MUSE Montpellier
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Modélisation de la ségrégation et du positionnement
du génome bactérien
Auteur(s): Parmeggiani A.
(Autres publications)
, 2018
Résumé: Sur la description de la recherche effectuée sur la ségrégation et le positionnement de l'ADN bactérien.
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Looping and Clustering: a statistical physics approach to protein-DNA complexes in bacteria
Auteur(s): Walter J.-C., Walliser N.-O., David G., Dorignac J., Geniet F., Palmeri J., Parmeggiani A., Wingreen Ned S., Broedersz Chase P.
(Affiches/Poster)
EMBO | EMBL Symposium: Cellular Mechanisms Driven by Liquid Phase Separation (Heidelberg, DE), 2018-05-14
Ref HAL: hal-01939915_v1
Exporter : BibTex | endNote
Résumé: The DNA shows a high degree of spatial and dynamical organization over a broad range of length scales. It interacts with different populations of proteins and can form protein-DNA complexes that underlie various biological processes, including chromosome segregation. A prominent example is the large ParB-DNA complex, an essential component of a widely spread mechanism for DNA segregation in bacteria. Recent studies suggest that DNA-bound ParB proteins interact with each other and condense into large clusters with multiple extruding DNA-loops.In my talk, I present the Looping and Clustering model [1], a simple statistical physics approach to describe how proteins assemble into a protein-DNA cluster with multiple loops. Our analytic model predicts binding profiles of ParB proteins in good agreement with data from high precision ChIP-sequencing – a biochemical technique to analyze the interaction between DNA and proteins at the level of the genome. The Looping and Clustering framework provides a quantitative tool that could be exploited to interpret further experimental results of ParB-like protein complexes and gain some new insights into the organization of DNA.
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