The value of MR radiomic features at a microscopic scale has not been explored in ovarian cancer. The objective of this study was to probe the associations of MR microscopy (MRM) images and MRM-derived radiomic maps with histopathology in high-grade serous ovarian cancer (HGSOC). Nine peritoneal implants from 9 patients with HGSOC were imaged ex vivo with MRM using a 9.4-T MR scanner. All MRM images and computed pixel-wise radiomics maps were correlated with the slice-matched stroma and tumor proportion maps derived from whole histopathologic slide images (WHSI) of corresponding peritoneal implants. Automated MRM-derived segmentation maps of tumor and stroma were constructed using holdout test data and validated against the histopathologic gold standard. Excellent correlation between MRM images and WHSI was observed (Dice index = 0.77). Entropy, correlation, difference entropy, and sum entropy radiomic features were positively associated with high stromal proportion (r = 0.97,0.88, 0.81, and 0.96 respectively, p < 0.05). MR signal intensity, energy, homogeneity, auto correlation, difference variance, and sum average were negatively associated with low stromal proportion (r = –0.91, –0.93, –0.94, –0.9, –0.89, –0.89, respectively, p < 0.05). Using the automated model, MRM predicted stromal proportion with an accuracy ranging from 61.4% to 71.9%. In this hypothesis-generating study, we showed that it is feasible to resolve histologic structures in HGSOC using ex vivo MRM at 9.4 T and radiomics.

We will discuss recent results: (i) on the theory of the Casimir torque between two gratings rotated by an angle theta with respect to each other, and (ii) on the theory and experiment on the Casimir force between interpenetrating gratings. These findings pave the way to the design of contactless quantum vacuum torsional spring and sensors with possible relevance to micro and nanomechanical devices.

In the first part of my talk I discuss the prediction and physical consequences of a new geometric zero-th order critical transition occurring to the Casimir torque at Theta=0 rotation angle between diffraction gratings. In the second part I discuss the theory predictions and proposal for the realization of a genuinely quantum thermal machine to be realized in systems out of thermal equilibrium. Here the recorded video: "https://online.kitp.ucsb.edu/online/flectro22/antezza/".

This is a broad-audience public lecture names "KITP Blackboard Lunch" I gave at the Kavli Institute of Theoreical Physics (KITP) at the University of California at Santa Barbara (UCSB) to discuss the physical basis of the core subjects of the KITP 7-week program "Emerging Regimes and Implications of Quantum and Thermal Fluctuational Electrodynamics" I organized at KITP. This lecture was devoted to the KITP permanent staff and to all the participants to the several KITP programs. Here the recorded video: "https://online.kitp.ucsb.edu/online/bblunch/antezza"

After a rapid introduction to the basic physical concepts of radiative heat transfer, I will focus on the study of the radiative heat transfer between two identical metallic one-dimensional lamellar gratings. To this aim I will present and exploit a modification to the widely used Fourier modal method, known as adaptive spatial resolution, based on a stretch of the coordinate associated with the periodicity of the grating. I show that this technique dramatically improves the rate of convergence when calculating the heat flux, and that there is a remarkable amplification of the exchanged energy, ascribed to the appearance of spoof-plasmon modes. By comparing our results to recent studies, we find a consistent quantitative disagreement with some previously obtained results going up to 50%.

Understanding the origin of the unique rheological properties of wheat gluten, the protein fraction of wheat grain, is crucial in bread-making processes and has raised questions of scientists for decades. Gluten is a complex mixture of two families of proteins, monomeric gliadins and polymeric glutenins. To better understand the respective role of the different classes of proteins in the supramolecular structure of gluten and its link to the material properties, we investigate here concentrated dispersions of gluten proteins in water with a fixed total protein concentration but variable composition in gliadin and glutenin. Linear viscoelasticity measurements show a gradual increase in the viscosity of the samples as the glutenin mass content increases from 7 to 66%. While the gliadin-rich samples are microphase-separated viscous fluids, homogeneous and transparent pre-gel and gels are obtained with the replacement of gliadin by glutenin. To unravel the flow properties of the gluten samples, we perform shear startup experiments at different shear-rates. In accordance with the linear viscoelastic signature, three classes of behavior are evidenced depending on the protein composition. As samples get depleted in gliadin and enriched in glutenin, distinctive features are measured: (i) viscosity undershoot suggesting droplet elongation for microphase-separated dispersions, (ii) stress overshoot and partial structural relaxation for near-critical pre-gels, and (iii) strain hardening and flow instabilities of gels. We discuss the experimental results by analogy with the behavior of model systems, including viscoelastic emulsions, branched polymer melts, and critical gels, and provide a consistent physical picture of the supramolecular features of the three classes of protein dispersions.

Electrochemical synthesis of NH3 is a carbon-free alternative to the traditional Haber-Bosch process. Obtaining NH3 from environmental pollutants, such as nitrates or nitrites, is a more practical route than from the nitrogen reduction reaction (NRR) due to the difficult cleavage of the inert triple bond of nitrogen gas. Here, we report a novel heterogeneous catalyst based on iron (Fe) single-atoms supported on two-dimensional MoS2 (Fe-MoS2) for the nitrate reduction reaction (NO3RR). Fe-MoS2 exhibits remarkable performance with a maximum Faradaic