Ref HAL: hal-04973970_v1
DOI: 10.1111/mmi.15347
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In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of discussion points centered around current challenges for the field, how these might be addressed, and how the field is likely to develop over the next 10 years. The Lorentz Center staff facilitated these discussions via tools aimed at optimizing productive interactions. This Perspective article is a summary of these discussions and reflects the state‐of‐the‐art of the field. It is expected to be of help to colleagues in advancing their own research related to prokaryotic chromosomes and inspiring novel interdisciplinary collaborations. This forward‐looking perspective highlights the open questions driving current research and builds on the impressive recent progress in these areas as represented by the accompanying reviews, perspectives, and research articles in this issue. These articles underline the multi‐disciplinary nature of the field, the multiple length scales at which chromatin is studied in vitro and in and highlight the differences and similarities of bacterial and archaeal chromatin and chromatin‐associated processes.

Ref HAL: hal-04953347_v1
DOI: 10.1016/j.str.2025.01.005
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Cytoskeletal-mediated membrane compartmentalization is essential to support cellular functions, from signaling to cell division, migration, or phagocytosis. Septins are cytoskeletal proteins that directly interact with membranes, acting as scaffolds to recruit proteins to cellular locations and as structural diffusion barriers. How septins interact with and remodel the lipid organization of membranes is unclear. Here, we combined minimal reconstituted systems and yeast cell imaging to study septin-mediated membrane organization. Our results show that at low concentrations membrane-diffusive septins self-assemble into sub-micrometric patches that co-exist with the septin collar at the division site. We found that patches are made of short septin filaments and that are able to modulate the lipid organization of membranes. Furthermore, we show that the polybasic domain of Cdc11 influences the membrane-organizing and curvature-sensing properties of septins. Collectively, our work provides understanding of the molecular mechanisms by which septins can support cellular functions intimately linked to membranes.

Ref HAL: hal-04973956_v1
DOI: 10.1101/2025.02.17.638629
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Ref HAL: hal-04932125_v1
Ref Arxiv: 2501.14935
Ref INSPIRE: 2872459
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We employ the renormalization group optimized perturbation theory (RGOPT) resummation method to evaluate the equation of state (EoS) for strange ($N_f=2+1$) and non-strange ($N_f=2$) cold quark matter at NLO. This allows us to obtain the mass-radius relation for pure quark stars and compare the results with the predictions from perturbative QCD (pQCD) at NNLO. Choosing the renormalization scale to generate maximum star masses of order $M=2 - 2.6 M_\odot$, we show that the RGOPT can produce mass-radius curves compatible with the masses and radii of some recently observed pulsars, regardless of their strangeness content. The scale values required to produce the desired maximum masses are higher in the strange scenario since the EoS is softer in this case. The possible reasons for such behavior are discussed. Our results also show that, as expected, the RGOPT predictions for the relevant observables are less sensitive to scale variations than those furnished by pQCD.

Ref HAL: hal-04931333_v1
DOI: 10.1038/s41586-024-08514-6
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Ref HAL: hal-04891856_v1
Ref Arxiv: 2412.09473
Ref INSPIRE: 2858867
DOI: 10.22323/1.473.0042
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A future multi-TeV muon collider would provide an important probe for Majorana neutrinos. A muon collider with a collision energy of $\sim$30 TeV would be sensitive to $\nu_e-\nu_\mu$ transition dipole moments of the order of $\sim 10^{-12}\mu_B$ and would be thus competitive with the latest astrophysical observation and laboratory experiments. Contrary to the latter, the muon collider would have the unique advantage of a direct and clean identification of lepton number and flavour violation. This would establish the Majorana nature of the neutrino and would provide crucial complementary information on the neutrino properties in the event of a (near) future observation at low-energy experiments. Additionally, a muon collider would improve by orders of magnitude the direct bounds on the Majorana neutrino mass matrix entries $m_{e\mu}$ and $m_{\mu\mu}$.

Ref HAL: hal-04741167_v2
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Commentaires: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in (citation of published article) and may be found at https://doi.org/10.1063/5.0236067