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(35) Production(s) de l'année 2022
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Fracture of silicate glasses: Micro-cavities and correlations between atomic-level properties 
Auteur(s): Zhang Z., Ispas S., Kob W.
(Article) Publié:
Physical Review Materials, vol. 6 p.085601 (2022)
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Therapeutic targeting of CDK4 kinase in pancreatic cancerusing functionalized single-walled carbon nanotubes
Auteur(s): Chavignon L., Blanc C., Morris May, Anglaret E.
(Affiches/Poster)
Chemontubes 2022 (San Sebastian, ES), 2022-04-24
Ref HAL: hal-03859686_v1
Exporter : BibTex | endNote
Résumé: Pancreatic cancer is one of the deadliest cancers with an increasing incidence due to a lack ofearly-stage diagnostics and effective treatment [1]. The RAS/RAF/ MAPK/CDK4 pathway is frequentlydysregulated in pancreatic cancer and CDK4 constitutes an attractive target since several drugs havebeen approved by the FDA to inhibit its activity: Abemaciclib, Ribociclib and Palbociclib [2,3] (Figure1) However these inhibitors are not efficient in monotherapy and have only been approved for breastcancer. In order to propose an efficient therapeutic strategy to target CDK4 in pancreatic cancer, wepropose to deliver Abemaciclib using carbon nanotubes.
Carbon nanotubes are promising materials for nanomedicine applications and especially fordrug delivery. [4] In this project, we adsorb Abemaciclib onto single-walled carbon nanotubes (SWNT)for delivery of the drug into pancreatic cancer cells. In order to study adsorption, we investigate thechanges in the optical signatures of SWNTs in the near-infrared (NIR) by coupling NIR absorption,photoluminescence and Raman spectroscopies. [5] Typical kinetic spectroscopic results, assigned tothe adsorption of Abemaciclib on SWNT, dispersed in water using carbomethylcellulose (CMC), arepresented in Figure 2. We discuss the results in terms of changes of the dielectric environment of thenanotubes, leading to modulation of their excitonic and optical properties. We have furtherinvestigated the inhibitory potential of SWNT-Abemaciclib on proliferation of PANC1 cells comparedto Abemaciclib alone and have determined the toxicthreshold of SWNT dispersed in CMC.
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Volume phase transition in PNIPAM/SWNTs hybrid microgels triggered by near infrared photo-thermal excitation
Auteur(s): D'ambrosio R., Phou T., Hehlen B., Blanc C., Anglaret E.
Conference: Chemontubes 2022 (San Sebastian, ES, 2022-04-24)
Ref HAL: hal-03859674_v1
Exporter : BibTex | endNote
Résumé: Poly(N-isopropyl acrylamide) (PNIPAM) is a thermo-responsive polymer which undergoes a reversible coil-to-globule transition in water at temperatures close to the human body temperature [1]. Consequently, PNIPAM-based microgels show a volume phase transition (VPT) under heating. Photo-responsive hybrid microgels have been prepared by incorporating gold nanoparticles in PNIPAM microgels [2]. The outstanding photo-thermal and optical properties of single-walled carbon nanotubes (SWNTs) make them promising candidates to prepare multi-responsive hybrid microgels. However, no thorough studies have been reported so far.
In this work, we report the preparation and properties of aqueous dispersions of PNIPAM/SWNTs hybrid microgels (Figure 1a). We study their structure by transmission electron microscopy and dynamic light scattering. We investigate their optical properties and changes when heated at the VPT by near infrared (NIR) absorption, Raman and photoluminescence (PL) spectroscopies [3]. Furthermore, we use optical microscopy (Figure 1b), light scattering and NIR Raman/PL spectroscopy to show that the VPT transition can be triggered by NIR photo-thermal excitation.
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