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CHEVALIER Carole
Doctorant en Contrat Doctoral avec Mission (Responsable :
PARMEGGIANI A.)
carole.chevalier
umontpellier.fr
Activités de Recherche: |
| Doctorat sur les mécanismes de régulation spatio-temporels de la traduction encadré par Andrea Parmeggiani et Jean-Charles Walter. |
Domaines de Recherche: - Physique/Physique/Biophysique
- Physique/Matière Condensée/Matière Molle
- Physique/Matière Condensée/Mécanique statistique
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Productions scientifiques :
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Modelling Spatio-temporal Dynamic of Ribosome During Translation 
Auteur(s): Chevalier C., Walter J.-C., Palmeri J., Parmeggiani A., Geniet F., Dorignac J., Walliser N.-O., Rivals Eric, Paulet Damien, David Alexandre
(Affiches/Poster)
7ème Journées Scientifiques du LabEx NUMEV (Montpellier, FR), 2018-11-27Texte intégral en Openaccess : 
Ref HAL: hal-01950298_v1
Exporter : BibTex | endNote
Résumé: Translation of messenger RNA (mRNA) leads to the production of proteins and is the last step of gene expression in cells. The dysregulation of translation can lead to all illnesses linked to the dysregulation of protein production, like cancer and neurodegenerative diseases.About ten years ago, a ribosomal density mapping strategy (Ribo-seq) was developed. The time is therefore ripe to apply theoretical physicsmethods to study translation. We model the movement of ribosomes on mRNA using the Totally Asymmetric Simple Exclusion Process (TASEP) which is an out of equilibrium one dimensional directed transport model. With Monte Carlo simulations and a mean field approach, we propose a way to calculate the speed of ribosomes from experimental data. Moreover, we provide preliminary results concerning the correlation between the speed of ribosomes and the occurrence rate of codons (RSCU).
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